Technology Platform

HSPG expressing Tumors

Harnessing Human Papillomavirus’ Natural Tropism to Target Tumors »
Viruses | Kines, et al.
Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity »
Frontiers in Oncology | Brunetti, et al.
Heparan sulfate signaling in cancer »
Trends in Biochemical Sciences | Knelson, et al.
The sweet and sour of cancer: glycans as novel therapeutic targets »
Nature Reviews Cancer, 2005 | Fuster, et al.
Heparan sulfate proteoglycans and cancer »
British Journal of Cancer | Blackhall et al.

Virus-Like Drug Conjugates

Immune checkpoint inhibition combined with targeted therapy using a novel virus‑like drug conjugate induces complete responses in a murine model of local and distant tumors »
Cancer Immunology, Immunotherapy | Huis in ‘t Veld, et al.
Virus-like particle-drug conjugates induce protective, long-lasting adaptive anti-tumor immunity in the absence of specifically targeted tumor antigens »
Cancer Immunology Research | Kines, et al.
An infrared dye-conjugated virus-like particle for the treatment of primary uveal melanoma »
Molecular Cancer Therapeutics | Kines, et al.
Human papillomavirus capsids preferentially bind and infect tumor cells »
International Journal of Cancer | Kines, et al.

Tumor Gene Therapy

Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer »
International Journal of Molecular Sciences | Hojeij, et al.
Ovarian cancer gene therapy using HPV-16 pseudovirion carrying the HSV-tk gene »
Ma, et al.


Choroidal Melanoma

Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model »
ARVO IOVS | Sen Ma, et al.
Uveal melanoma: relatively rare but deadly cancer »
Nature Eye | Kaliki. et al.
Metastasis of Uveal Melanoma: Millimeter-by-Millimeter in 8033 Consecutive Eyes »
Archives of Ophthalmology | Shields, et al.
Clinical Factors in the Identification of Small Choroidal Melanoma »
Canadian Journal of Ophthalmology | Shields, et al.
Collaborative Ocular Melanoma Study (COMS) Randomized Trial of I-125 Brachytherapy for Medium Choroidal Melanoma »
Ophthalmology | Melia, et al.

Choroidal Metastases

Survey of 520 Eyes with Uveal Metastases »
Ophthalmology | Shields et al.

Non-Muscle Invasive Bladder Cancer

Transurethral resection of bladder tumour (TURBT) »
Translational Andrology and Urology | Kim, et al.
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) – 2019 Update »
European Urology | Babjuk et al.
Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline »
The Journal of Urology | Chang et al.